Meropenem pharmacokinetics in children: series of cases

Geisa Cristina da Silva  Alves; Farah Maria Drumond Chequer; Cristina  Sanches

doi:10.30968/rbfhss.2018.093.002

Meropenem pharmacokinetics in children: series of cases

Authors

Geisa Cristina da Silva Alves
Farah Maria Drumond Chequer
Cristina Sanches

DOI:

https://doi.org/10.30968/rbfhss.2018.093.002

Abstract

Daily doses of antibiotics recommended for children are based on studies in healthy adult volunteers, so this study aimed to describe the pharmacokinetic/pharmacodynamic characteristics of meropenem in children and to verify whether plasma concentrations were within the range therapy. This is a series of cases, which included 4 children, aged 02-12 years old using meropenem dose empirical, 8/8h in 75% of children. The study was conducted in a pediatric hospital from March 2016 to March 2017. Only one child had the result of the culture of biological material recorded in medical records at the time of collection. We observed high inter-patient variability of pharmacokinetic parameters, however plasma concentrations of meropenem were effective in 100% of the study population considering the parameter 40%f T>CIM to CIM of 0.25μg/mL.

Downloads

Download data is not yet available.

Downloads

Published

2018-09-30

How to Cite

Alves GC da S, Chequer FMD, Sanches C. Meropenem pharmacokinetics in children: series of cases. Rev Bras Farm Hosp Serv Saude [Internet]. 2018Sep.30 [cited 2024Nov.22];9(3):e093.002. Available from: https://rbfhss.org.br/sbrafh/article/view/380

Download Citation

Issue

Vol. 9 No. 3 (2018): Jul-Sep

Section

ORIGINAL ARTICLES

License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Serlf-archiving policy

This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.