Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study

Larissa PAVANELLO; Fátima G.  FARHAT; Rafaela P.  CARVALHO; Hellen T.  GREGÓRIO

doi:10.30968/rbfhss.2021.122.0573

Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study

Authors

Larissa PAVANELLO https://orcid.org/0000-0003-3469-4226
Fátima G. FARHAT https://orcid.org/0000-0003-4582-7426
Rafaela P. CARVALHO https://orcid.org/0000-0002-3251-3367
Hellen T. GREGÓRIO https://orcid.org/0000-0002-3161-2013

DOI:

https://doi.org/10.30968/rbfhss.2021.122.0573

Abstract

Objective: To assess the prevalence of pDDI involving antimicrobials and other standardized drugs in a large general hospital in the interior of São Paulo. Methods: quantitative study, with cross-sectional design and data collection by documentary analysis of hospital prescriptions from April to June 2017. Results: 66 clinically relevant pDDI were found, which corresponded to approximately 7.3% of antimicrobial prescriptions, being 93.9% (62) contraindicated / severe and 6.1% (4) moderate. There was no difference in the prevalence of clinically relevant pDDIs between critical and non-critical inpatient, in addition to all contraindicated interactions (10) having occurred in the clinical and surgical units. The most prevalent pDDI were, with respective degrees of documentation, between vancomycin and amikacin (47% - reasonable), clarithromycin and simvastatin (13.6% - good), and ciprofloxacin and simvastatin (7.6% - good). Conclusion: For the proper prevention of potential drug-related problems, mechanisms to guarantee the quality of prescriptions by trained clinical pharmacists are of fundamental importance, in addition to alert systems and drug interaction information for the health team, then ensuring quality pharmacotherapy and patient safety.

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Published

2021-06-30

How to Cite

PAVANELLO L, FARHAT FG, CARVALHO RP, GREGÓRIO HT. Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study. Rev Bras Farm Hosp Serv Saude [Internet]. 2021Jun.30 [cited 2024Nov.22];12(2):573. Available from: https://rbfhss.org.br/sbrafh/article/view/573

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Issue

Vol. 12 No. 2 (2021): Apr-Jun

Section

ORIGINAL ARTICLES

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