Pharmaceutical interventions and their clinical outcomes in an inpatient post-transplant unit

  • LIANA SILVEIRA ADRIANO
  • BRUNA CRISTINA CARDOSO MARTINS
  • LÍVIA FALCÃO LIMA
  • RAFAELA MICHELE DE ANDRADE CAVALCANTE
  • FRANCISCO ROBERTO PEREIRA DE OLIVEIRA
  • VANESSA PINTO MAGALHÃES
  • PAULO YURI MILEN FIRMINO
  • MARTA MARIA DE FRANÇA FONTELES
  • EUGENIE DESIRÈE RABELO NÉRI

Abstract

To contribute to the formation of knowledge in Brazil about the impact of the clinical pharmacist's role in  the care of inpatient post-transplant by analyzing the results of the pharmaceutical interventions performed.  A  descriptive  study  was  conducted  from  January  to  July/2014.  Data  were  collected  from  the  records  of  the  Clinical  Pharmacy  Service  (medication  reconciliation,  prescription  analysis  and  pharmacotherapeutic  follow-up), including all patients with drug-related problems and documented pharmaceutical interventions.  Epidemiological  variables  and  related  to  the  clinical  activities  of  the  pharmacist  were  described.  A  total   of  131  patients  had  drug-related  problems,  especially,  during  “Pharmacoterapeutic  follow-up”.  The  most   frequent  categories  were:  “not  prescribed  required  medicine”  (125;  21.7%),  “overdosing”  (97;  16.8%)  and   “underdosing”  (93;  16.1%).  The  main  drugs  involved  were  “ganciclovir”  (81;  13.4%)  and  “tacrolimus”  (33;   5.5%). The pharmaceutical interventions included “dose/adequacy” (193; 33.4%), “inclusion” (122; 21.1%) or  “suspension”  (122;  21.1%)  of  medication.  The  main  clinical  outcomes  were  “prevention”  (481;  83.4%)  or  “improvement”  (59;  10.2%)  of  health  problems,  such  as  “adverse  effects”  (170;  29.5%),  “infection”  (133;  23%) and “rejection” (41; 7.1%), being identified a significant relationship (p<0.05) between the acceptance of interventions and these outcomes, as well as between the non-acceptance and the occurrence of negative outcomes  associated  with  medication.    Our  findings  demonstrated  that  the  pharmaceutical  interventions,   carried at all stages of care to inpatient post-transplant, integrated with the multidisciplinary team, were able to provide clinical outcomes in the prevention and improvement in health problems related to medication, such as adverse events, infection and rejection.

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Published
2019-03-11
How to Cite
ADRIANO, L. S., MARTINS, B. C. C., LIMA, L. F., CAVALCANTE, R. M. D. A., OLIVEIRA, F. R. P. D., MAGALHÃES, V. P., FIRMINO, P. Y. M., FONTELES, M. M. D. F., & NÉRI, E. D. R. (2019). Pharmaceutical interventions and their clinical outcomes in an inpatient post-transplant unit. Revista Brasileira De Farmácia Hospitalar E Serviços De Saúde, 8(1). Retrieved from https://rbfhss.org.br/sbrafh/article/view/284
Section
ARTIGOS PUBLICADOS