Evaluation of reports of suspected adverse drug reactions in transplant patients of a sentinel hospital in Fortaleza-Ceará

Authors

  • BRUNA CRISTINA CARDOSO MARTINS
  • VANESSA PINTO MAGALHÃES
  • RAFAELA MICHELE DE ANDRADE CAVALCANTE
  • FRANCISCO ROBERTO PEREIRA DE OLIVEIRA
  • ELANA FIGUEIREDO CHAVES
  • MARJORIE MOREIRA GUEDES
  • PAULO YURI MILEN FIRMINO
  • EUGENIE DESIRÉE RABELO NÉRI

Keywords:

Farmacovigilância, Sistemas de Notificação de Reações Adversas a Medicamentos, Transplante

Abstract

The study aimed to describe and analyze reports of suspected Adverse Drug Reactions (ADRs) at the transplant service of a sentinel hospital in Fortaleza, Ceará. A descriptive, cross-sectional, observational study was performed using, as a secondary source, notification forms of suspected ADRs of risk management in 2014. There were 35 reports involving transplanted patients, 52 drugs and 50 reactions in the hospital. All notifications were made spontaneously, being 94.5% reported by a pharmacist. The most affected patient age groups were 50-60 years and > 60, with an average age of 51.79 (± 14.09) years. Adverse reactions affected mainly men (55%), kidney transplant patients (69.69%). The major drugs involved were ganciclovir (21.2%), tacrolimus (13.5%) and sodium mycophenolate (11.5%). Most ADRs were related to skin diseases and related disorders (23%), 77% pruritus and 23% erythema. Analyzing the causality classification of ADRs, 46% were classified as possible and 88% were classified, regarding severity, as moderate. The findings indicate that the suspicions of reactions notified in transplant patients were associated with the pharmacotherapy commonly established during post-transplantation, leading to the need for monitoring.

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Published

2019-03-11

How to Cite

1.
MARTINS BCC, MAGALHÃES VP, CAVALCANTE RMDA, OLIVEIRA FRPD, CHAVES EF, GUEDES MM, FIRMINO PYM, NÉRI EDR. Evaluation of reports of suspected adverse drug reactions in transplant patients of a sentinel hospital in Fortaleza-Ceará. Rev Bras Farm Hosp Serv Saude [Internet]. 2019Mar.11 [cited 2022Nov.30];8(1). Available from: https://rbfhss.org.br/sbrafh/article/view/282

Issue

Section

ARTIGOS PUBLICADOS

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