Potential drug interactions in patients with hematologic diseases attended in a public hemotherapy unit of Goias
Keywords:
Interações medicamentosas. Doenças hematológicas. Hemofilia. Doença de von Willedrand. Anemia falciforme.Abstract
Objectives: The objective of this study was to describe the incidence of potential drug interactions (DIs) between the prescribed and self-medicated drugs of patients with hematological diseases treated at a public hemotherapy unit.
Methods: It conducted a cross-sectional analytical quantitative study in patients with hematological diseases in the period from July to November 2014.
Results: They were interviewed 54 patients aged over 18 years, mostly male, with deficiency of coagulation factors, such as hemophilia and von Willebrand disease, or sickle cell disease, registered and monitored in the Goiás Blood Center. Of the 246 drugs used, 177 were prescribed and 69 self-medication, with an average of 5 drugs per patient and Standard Deviation (SD) of 2.1. It was observed that 88.9% of patients had risk of DIs, with average of 5 DIs per patient (SD=3.6). From the analysis of interactions between drugs, ethanol, tobacco and food were identified 224 potential interactions, presenting the risk factors with significant, adverse reactions associated with drug-drug interactions and self-medication related to drug-tobacco interactions. The class of drugs with greater frequency of use was the hematopoietic group, nervous system and musculoskeletal system, between the last two are the analgesics and anti-inflammatories.
Conclusion: this study demonstrates the high incidence of potencial DIs in the study group, emphasizing the importance of the pharmacist's role in order to contribute to the multidisciplinary team in the reduction of risks from pharmacotherapy.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Serlf-archiving policy
This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.
