Construction and validation of educational booklets regarding oral antineoplastics
DOI:
https://doi.org/10.30968/rbfhss.2024.153.1117Abstract
Objective: To construct and validate educational pamphlets on oral antineoplastic therapy for patients with oncologic or hematologic diseases treated on an outpatient basis. Method: We carried out this research on two stages: a) Elaboration of educational pamphlets by the researchers, containing information regarding indication, administration mode, adverse effects, storage, and other precautions for the listed oral antineoplastics: Anagrelide, Cyclophosphamide, Chlorambucil, Melphalan, Lomustine, Mercaptopurine, Methotrexate, Mitotane, Pazopanib, Sorafenib, Temozolomide, Thioguanine, Ruxolitinib, and Tretinoin; b) Validation of the developed materials through a median grade among experts in the field (oncology and/or hematology pharmacists), using the Delphi Method, evaluating layout and content through a Likert scale. Data dispersion was assessed through the interquartile range (IQR), and adequate grade was defined as a median above 3. Results: The educational pamphlets were developed using national and international references, encompassing necessary information for the adequate and safe use of medications by patients. The initial validation involved 19 pharmacists specialized in oncology and/or hematology, spread across the national territory. In the first evaluation round, there was disagreement among experts on two issues, both related to the material’s content (highlighted sections and language used). After addressing points of disagreement, the pamphlets were validated by adequate grade among eight experts who remained in the study for the second round. Conclusion: It was possible to validate by experts the educational content of booklets containing written guidance on pharmacotherapy that will be delivered to the patient/caregiver, covering topics relevant to different medications, containing information with assertive scientific evidence, combining illustrations and language that is easy to understand by the population.
Downloads
References
World Health Organization. Cancer. World Health Organization, 2022. Disponível em: https://www.who.int/news-room/fact-sheets/detail/cancer. Acesso em: 22 nov. 2023.
Ministério da Saúde. O que é câncer? Instituto Nacional de Câncer - INCA, 2022. Disponível em: https://www.gov.br/inca/pt-br/assuntos/cancer/o-que-e-cancer. Acesso em: 22 nov. 2023.
Perez T, Montaleytang M, Boisseranc C, et al. Retour d’expérience en pharmacie clinique oncologique. Annales Pharmaceutiques Françaises. 2020;78:70–75. doi: 10.1016/j.pharma.2019.09.002.
Bartel SB. Safe practices and financial considerations in using oral chemotherapeutic agents. American Journal of Health-System Pharmacy. 2007;64:S8–S14. doi: 10.2146/ajhp070036.
Jimmy B, Jose J. Patient Medication Adherence: Measures in Daily Practice. Oman Medical Journal. 2020;26:155–159. doi: 10.5001/omj.2011.38.
Occhipinti S, Petit-Jean E, Pinguet F, et al. Implication du pharmacien dans l’accompagnement des patients sous antican-céreux oraux : état des lieux dans les centres de lutte contre le cancer (CLCC). Bulletin du Cancer. 2017;104:727–734. doi: 10.1016/j.bulcan.2017.06.012. 12
Greer JA, Amoyal N, Nisotel L, et al. A systematic review of adherence to oral antineoplastic therapies. Oncologist. 2016;21(3):354-76. doi: 10.1634/theoncologist.2015-0405
McCue DA, Lohr LK, Pick AM. Improving adherence to oral cancer therapy in clinical practice. Pharmacotherapy. 2014;34(5):481-94. doi: 10.1002/phar.1399
Clayton LH. TEMPtEd: development and psychometric properties of a tool to evaluate material used in patient education. Journal of Advanced Nursing. 2009;65:2229–2238. doi: 10.1111/j.1365-2648.2009.05049.x.
Marques JBV, Freitas D. Método DELPHI: caracterização e potencialidades na pesquisa em Educação. Pro-Posições. 2018;29:389–415. doi: 10.1590/1980-6248-2015-0140.
Castro MS, Pilger D, Fuchs FD, et al. Development and validity of a method for the evaluation of printed education material. Pharm Pract (Granada). 2007;5:89–94. doi: 10.4321/s1886-36552007000200007.
da Rocha C, Carlotto J, Zanis Neto J. Analysis of the interventions in antineoplastic therapy by a clinical pharmacy service at a tertiary hospital in Brazil. J Oncol Pharm Pract. 2022 Jul;28(5):1049-1055. doi: 10.1177/10781552211017650.
Anversa Sugisaka AC, Mari Salvi Andrzejevski V, Rotta I. Validação de Materiais Educativos para Orientação de Pacientes em Tratamento de Câncer de Mama com Hormonioterapia. Rev. Bras. Cancerol. [Internet]. 29º de setembro de 2020 [citado 16º de junho de 2024];66(4):e-051079. Disponível em: https://rbc.inca.gov.br/index.php/revista/article/view/1079
Slaytor EK, Ward JE. How risks of breast cancer and benefits of screening are communicated to women: analysis of 58 pamphlets. BMJ 1998; 317: 263-264
Doak LG, Doak CC, Meade CD. Strategies to improve cancer education materials. Patient Educ Couns 1996; 23:1305-1312.
Wells JA. Readability of HIV/AIDS educational materials: the role of the medium of communication, target audience, and producer characteristics. Patient Educ Couns 1994; 24:249-259
Skrabal Ross X, Gunn KM, Suppiah V, et al. A review of factors influencing non-adherence to oral antineoplastic drugs. Supportive Care in Cancer. 2020;28. doi: 10.1007/s00520-020-05469-y.
Jacobs JM, Ream ME, Pensak N, et al. Patient Experiences With Oral Chemotherapy: Adherence, Symptoms, and Quality of Life. Journal of the National Comprehensive Cancer Network. 2019;17:221–228. doi: 10.6004/jnccn.2018.7098.
Halfdanarson TR, Jatoi A. Oral Cancer Chemotherapy: The Critical Interplay Between Patient Education and Patient Safety. Current Oncology Reports. 2010;12:247–252. doi: 10.1007/s11912-010-0103-6.
Timmers L, Boons CCLM, Kropff F, et al. Adherence and patients’ experiences with the use of oral anticancer agents. Acta Oncologica. 2013;53:259–267. doi: 10.3109/0284186x.2013.844353.
Bhatia S, Landier W, Shangguan M, et al. Nonadherence to Oral Mercaptopurine and Risk of Relapse in Hispanic and Non-Hispanic White Children With Acute Lymphoblastic Leukemia: A Report From the Children’s Oncology Group. Journal of Clinical Oncology. 2012;30:2094–2101. doi: 10.1200/jco.2011.38.9924.
Friedman AJ, Cosby R, Boyko S, et al. Effective Teaching Strategies and Methods of Delivery for Patient Education: A Systematic Review and Practice Guideline Recommendations. Journal of Cancer Education. 2011;26:12–21. doi: 10.1007/s13187-010-0183-x.
Kahn JM, Athale UH, Clavell LA, et al. How Variable Is Our Delivery of Information? Approaches to Patient Education About Oral Chemotherapy in the Pediatric Oncology Clinic. Journal of Pediatric Health Care. 2017;31:e1–e6. doi: 10.1016/j.pedhc.2016.06.004.
Araújo DC, Finatto MJ. Pharmacy and linguistics: strategies for promoting health literacy. Rev Bras Farm Hosp Serv Saude. 2023;15(1):1141. doi: 10.30968/rbfhss.2023.151.1141.
Muluneh B, Deal A, Alexander MD, et al. Patient perspectives on the barriers associated with medication adherence to oral chemotherapy. Journal of Oncology Pharmacy Practice. 2018;24:98–109. doi: 10.1177/1078155216679026.
Kaptein AA, Schoones JW, van der Meer PB, et al. Psychosocial determinants of adherence with oral anticancer treatment: “we don’t need no education.” Acta Oncologica. 2020;60:87–95. doi: 10.1080/0284186x.2020.1843190.
Oliveira CS, Silva MP, Miranda ÍKSPB, et al. Impact of clinical pharmacy in oncology and hematology centers: A systematic review. Journal of Oncology Pharmacy Practice: Official Publication of the International Society of Oncology Pharmacy Practitioners. 2021;27:679–692. doi: 10.1177/1078155220976801.
Kaupp K, Scott S, Minard LV, et al. Optimizing patient education of oncology medications: A quantitative analysis of the patient perspective. Journal of Oncology Pharmacy Practice. 2019;25:1445–1455. doi: 10.1177/1078155219843675.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Authors
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Serlf-archiving policy
This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.
