Analysis of suspected adverse reactions to anesthetic drugs during cesarean delivery in a cohort of women from a teaching maternity hospital in Ceará (Brazil)
DOI:
https://doi.org/10.30968/rbfhss.2022.134.0843Abstract
Objective: To analyze and describe post-surgical adverse events in pregnant women treated at a teaching maternity hospital in the city of Fortaleza, Ceará. Methods: Cross-sectional, quantitative study. Medical records and interviews of women in the postpartum cesarean section were used, in a teaching maternity hospital, in the city of Fortaleza, in the state of Ceará. All patients submitted to the anesthesia application technique were selected. The materials used for this research and the specific data were determined such as variables, education, complications, habits, allergies, pre-existing diseases, medications, reactions and applied procedures. Results: The research included 88 patients. Most patients are aged between 20 and 29 years, 46.59% (n= 41), and 30 to 39 years, 42.05% (n= 37). The predominant type of anesthesia was the spinal epidural used in 93% (n= 82) of the patients. Post-anesthetic reactions were: flatulence 22.63% (n= 55), itchy face 17.69% (n= 43) and vomiting 10.29% (n= 25). Bupivacaine was the only anesthesia used in all women who underwent cesarean section, 100% (n=88). Adjunctive drugs were used, such as morphine 97.72% (n= 86) and fentanyl 55.68% (n=49). The patients’ adverse events were mild 62.50% (n= 55) to moderate 37.50% (n= 33). Conclusion: The pregnant women received the same anesthetic (bupivacaine), and presented some reactions such as headache, flatulence, facial itching and vomiting. These data reinforce the importance of follow-up by the pharmacist to minimize possible adverse reactions and drug interactions. Furthermore, it is important to use pharmacovigilance resources as a tool for adverse pharmacological events. It is suggested to deepen the analysis for a longer period of time and cover the population of high-risk pregnant women in Ceará.
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Silveira GTV. Desconstrução da normalização do parto cesariano no Brasil. 2020. Monografia (Graduação em Enfermagem) – Faculdade de Ciências da Educação e da Saúde, Centro Universitário de Brasília, Brasília. 2020.
Pinto KB, Chagas LTPC, Alexandra L et al. Panorama de mortalidade materna no Brasil por causas obstétricas diretas. Research, Society and Development. 2022; 11(6). doi: 10.33448/rsd-v11i6.28753
Filho MB, Santos CC. Cirurgias cesáreas: a evolução temporal, tendência epidêmica, propostas e recomendações da OMS, dúvidas e desafios atuais. Rev Bras Saúde Mater Infant. 2018;18(4). doi: 10.1590/1806-93042018000400010
Fonseca FMV. Influência do tipo de parto no aleitamento materno: Revisão Sistemática da Literatura. Instituto Politécnico de Viseu. 2020;1-73.
Carvalho CSRA, Paula E, Ribeiro WA. Cuidado humanizado no parto cesariana na ótica da enfermagem. 2021;1(2). doi: 10.53612/recisatec.v1i2.20
Santos MC. Lista de verificação para partos seguros da OMS: Aplicação de práticas essenciais em um hospital escola. 2018.
Siaulys MM. Condutas em Anestesia Obstétrica. Ed. Elsevier Editora Ltda. 2012
Cunha AA, Gribel GPC, Palmiro, A. Analgesia e anestesia farmacológica em Obstetrícia. São Paulo: Federação Brasileira das Associações de Ginecologia e Obstetrícia (Febrasgo), 2018. (Protocolo Febrasgo – Obstetrícia, nº 98/Comissão Nacional Especializada em Assistência ao Abortamento, Parto e Puerpério).
Silva ALA, Santos APS, Matos SGS, et al. Diabetes Mellitus Gestacional com ênfase nas Gestantes de Alto Risco. Id on Line Rev Psic. 2021;15(58):278-291. doi: 10.14295/idonline.v15i58.3328
Conselho Regional de Farmácia de Minas Gerais. Notificações e reações adversas a medicamentos (RAM). 2021. Belo Horizonte-MG.
Naranjo CA, Busto U, Sellers EM et al. A method for estimating the probability of adverse drug reactions. Clinical Pharmacology & Therapeutics. 1981; 30(2):239-245.
Oliveira LAM, Galvão MPSP, Soares YKC, et al. Nursing care for pregnant with hypertensive syndrome: integrative review. Brazilian Journal of Surgery and Clinical Research. 2022;23(2):159-164.
Kahhale S, Francisco RPV, Zugaib M. Pré-Eclampsia. Rev Med. 2018;97(2):226-34. doi: 10.11606/issn.1679-9836.v97i2p226-234
Costa J, Silva LN, Barros NB, et al. Atenção primária a grávidas em relação ao consumo de mips na gravidez e os efeitos teratogênicos. Brazilian Journal of Development. 2021;7(9). doi: 10.34117/bjdv7n9-376
Bertoco MC, Azambuja KS. Uso de antiagregantes plaquetários na pré-Eclampsia: uma revisão narrativa. REA med. 2022;3. doi: 10.25248/reamed.e9741.2022
Campos PRS, Oliveira ACC, Santos NCF, et al. The importance of nutritional follow up of pregnant women in HIV/AIDS treatment. Research, Society and Development. 2022;11(5). doi: 10.33448/rsd-v11i5.28331
Kumar S, Chandra KN, Ayub A. Síndrome de vasoconstrição cerebral reversível, uma causa rara de cefaleia pós-parto: Visão da anestesia. Rev. Bras. Anestesiol. 2019.69(3):311-314. doi: 10.1016/j.bjan.2018.11.001
Tyagi A, Ramanujam M, Sethi AK, et al. Utilidade clínica da extensão do volume peridural após doses subaracnoídeas reduzidas: um estudo clínico randomizado. Brazilian Journal of Anesthesiology. 2020; 71(1):31-37. doi: 10.1016/j.bjane.2020.12.005
Brito MPC, Matos RS, Quirino, GMC, et al. Complicações pós- -operatórias relacionadas à anestesia em pacientes submetidos a cirurgias ginecológicas e obstétricas. Health Residencies Journal. 2022;3(14). doi: 10.51723/hrj.v3i14.358.
Ferreira JCL, Silva MCV, Mussarelli YF, et al. Cuidados humanizados no pós operatório de cesárea: revisão integrativa. Rev Faculdades do Saber. 2021;6(13).
Cherobin ACFP, Tavares GT. Safety Of local anesthetics. An Bras Dermatol. 2020; 95(1):82-90. doi: 10.1016/j.abd.2019.09.025
Ferrarezi WPP, Braga AFA, Ferreira VB, et al. Anestesia espinhal para cesariana eletiva. Emprego da associação de bupivacaína a diferentes doses de fentanil: ensaio clínico randomizado. Brazilian Journal of Anesthesiology. 2021;71(6):642-648. doi: 10.1016/j.bjane.2021.03.030
Uppal V, Retter S, Casey M, et al. Efficacy of Intrathecal Fentanyl for Cesarean Delivery: A Systematic Review and Meta-analysis of Randomized Controlled Trials With Trial Sequential Analysis. Anesth Analg. 2020;130(1):111-125. doi: 10.1213/ANE.0000000000003975
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