Associations between high-alert medications and potential drug-drug interactions in a pediatric intensive therapy unit
DOI:
https://doi.org/10.30968/rbfhss.2023.143.0802Abstract
Objective: To analyze associations between high-alert medications and potential drug-drug interactions in pediatrics. Methods: The medical prescriptions of patients admitted to the pediatric intensive care unit within a period of six months were analyzed. The characterization of pDDI involving the high alert medications (HAM) was performed using the Micromedex® software. To identify factors associated with the incidence of pDDI found, inferential statistical tests were performed using the R software version 4.1.0. The significance level adopted was 5% (p<0.05). Results: Of the prescribed drugs, 27.9% were HAM. Seventeen of them were involved in some pDDI. Fentanyl, midazolam, methadone and regular insulin were associated with an increased chance of a patient having some pDDI. Fentanyl, midazolam, potassium chloride 10%, phenobarbital, methadone, clobazam, ketamine and morphine were associated with increased the average pDDI per patient. Having at least one HAM in the pDDI increased the severity of the pDDI, and fentanyl, potassium chloride 10%, phenobarbital, methadone, clobazam, ketamine, dexmedetomidine, morphine and tramadol were associated with severity. The amount of HAM involved in pDDI is directly correlated with the severity of pDDI. Conclusion: Knowledge of the factors associated with the incidence of pDDI involving HAM enables the reduction of adverse drug events, and consequently the promotion of pediatric patient safety.
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