Clinical pharmacy and serum concentration of Vancomycin: from therapeutic monitoring to change of conduct in inpatient units
DOI:
https://doi.org/10.30968/rbfhss.2021.124.0697Keywords:
therapeutic monitoring, vancomycin; tenal replacement therapy.Abstract
Objective: To compare, by means of plasma concentration, the prescribed dose (loading dose and full dose) of vancomycin in patients undergoing hemodialysis at Hospital Santa Casa de Misericordia in Maringa. Method: Retrospective cohort study with patients hospitalized from July/2020 to July/2021 who were on renal replacement therapy and used vancomycin. Data were collected from the electronic medical record considering the serum concentrations and clinical information of the patients, being organized in spreadsheets and the comparison of the medians of the two groups performed by the statistical tests of Mann-Whitney and Kruskal- Wallis. Result: A total of 51 patients were included in the study, 13 who received a mean loading dose of 19.01 mg/kg and 38 patients with full dose (1,000mg every 8 - 12h) before adjustment for dialysis, with median aged 55 years and 64.5 years, respectively. The amount of pharmaceutical adjustments performed, considering the serum concentration and the number of vouchers performed, were similar in both groups. The first trough obtained was statistically lower in patients with a loading dose (20 μg/mL) when compared to a full dose (33.2 μg/mL). Furthermore, the full dose group presented about 60% of the results of vouchers, during treatment, above the recommended therapeutic range. It was not possible to assess therapeutic failure and patient survival. Conclusion: Patients who received a loading dose reached the therapeutic serum level of vancomycin more quickly and with a lower risk of toxicity, remaining within the target during the entire treatment.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Authors
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Serlf-archiving policy
This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.
