Profile and management of theoretical potential drug interactions in ICU prescriptions

Authors

  • PRISCILA GAVA MAZZOLA
  • ALINE TEOTONIO RODRIGUES
  • ALINE APARECIDA DA CRUZ
  • MÉCIA DE MARIALVA
  • SILVIA GRANJA
  • SIMONE CRISTINA MODA BATTAGLINI
  • ANTÔNIO LUIS EIRAS FALCÃO
  • PATRICIA MORIEL

Keywords:

Interações de Medicamentos, Unidade de Terapia Intensiva.

Abstract

Objective: The aim of this study was to evaluate the existence of Theoretical Potential Drug Interactions (TPDI) in prescriptions made at the Intensive Care Unit (ICU) of a Public Hospital (Hospital de Clinicas - UNICAMP), and also quantify and classify them based on level of severity, thus providing a profile of the prescriptions of this sector.

Methods: Between the months of January to June of 2011, a total of 195 prescriptions to patients aged 18 years or older who had been hospitalized for more than 24 hours in adult Intensive Care Unit were evaluated.

Results: During the study period, 172 different types of medications were prescribed, with an average of 12.9 ± 4.3 by prescription. Among the prescriptions evaluated, 88.2% had theoretical potential drug interactions that resulted in an average of 4.7± 4.9 by prescription. The 915 TPDI observed in that prescriptions were classified as contraindicated (20), major (257), moderate (516) and minor (122), using information from the database MICROMEDEX ®. These TPDI were reported to the medical team according to their severity and the need for clinical management.

Conclusion: This research collaborates to the delimitation of the pharmacotherapy procedures used in intensive care, demonstrating that there is a high incidence of Theoretical Potential Drug Interactions in them. It also highlights the Clinical Pharmacist’s contribution in this area, helping the multidisciplinary team to reduce the risks in drug therapy.

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Published

2019-03-11

How to Cite

1.
MAZZOLA PG, RODRIGUES AT, CRUZ AAD, MARIALVA MD, GRANJA S, BATTAGLINI SCM, FALCÃO ALE, MORIEL P. Profile and management of theoretical potential drug interactions in ICU prescriptions. Rev Bras Farm Hosp Serv Saude [Internet]. 2019Mar.11 [cited 2024Nov.8];2(2). Available from: https://rbfhss.org.br/sbrafh/article/view/69

Issue

Section

ARTIGOS PUBLICADOS

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