Oral anticoagulants for the treatment of venous thromboembolism and non-valvular atrial fibrillation: a cost analysis
DOI:
https://doi.org/10.30968/rbfhss.2021.121.0592Abstract
Objective: To analyze the total direct cost of anticoagulant therapies indicated for the chronic treatment of patients with non-valvular atrial fibrillation (AF) and the acute treatment of venous thromboembolism (VTE) in the perspective of a tertiary teaching hospital and the national public health system. Methods: Therefore, the review of the treatment regimens that included all the oral anticoagulants based on nationals and internationals guidelines. The cost data were extracted and performed the simulation of the costs of pharmacological therapy and exams for monitoring therapeutic goals. The time horizon was defined by 365 days for AF and 90 days for TEV. Results: The treatment cost of 90 days in VTE was: rivaroxaban (USD $82,96 to USD $156,15), apixaban (USD $110,25 to USD $123,11), edoxaban (USD $106,56 to USD $265,15), dabigatran (USD $150,71 to USD $249,98) and warfarin (USD $54,94 to USD $159,66). While the treatment cost of AF was: rivaroxaban (USD $270,35 to USD $508,89), apixaban (USD $414,86 to USD $463,26), edoxaban (USD $402,41 to USD $477,78), dabigatran (USD $414,86 to USD $416,24) and warfarin (USD $20,03 to USD $43,54). Conclusion: Warfarin presented the lowest treatment cost for both comorbidities. However, although direct oral anticoagulants (DOACs) are always associated with higher price ranges, were observed price ranges in VTE treatment where DOACs proved to be economically more advantageous than warfarin, still requiring complete economic assessments.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Serlf-archiving policy
This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.
