Evaluation of potential drug interactions in hospital admission
Introduction: In clinical practice, drugs association is common and can lead to drug interactions (MI), which can lead to an avoidable adverse events that may need a for pharmaceutical intervention. Objective: The objective of this study is to identify and evaluate the drug interactions present on prescriptions of patients at the adult medical clinic of a hospital in Rio de Janeiro, at admission moment. Method: Cross-sectional study involving the analysis of information through the database (e-sus). Interactions were classified according to the Micromedex database. Results: A total of 177 prescriptions were evaluated. The main underlying disease was the neoplasias (36.16%), and the main cause of hospitalization was pain (8.5%). Of the prescriptions evaluated, 81.93% had some potential MI. A total of 180 types of MI were identified, representing 600 IM. Considering the degree of severity, 60% (358) were classified as severe MI, 38% (229) moderate, 1% (7) low and contraindicated. The most prevalent drug involved in MI was dipyrone (43.8%). The most frequent severe MI was between Dipirona + Enoxaparin (9.4%). Among moderate MI, Dipirone + Captopril (14.8%) was the most frequent and among the low ones, Furosemide + Hydralazine (42.9%). The contraindicated MI appeared in a similar way with 16.7% each. According to the scientific evidence found, serious MI had mostly reasonable documentation (59.5%), while the moderate ones had the majority of documentation classified as good (48.9%). Conclusion: In this context it is reasonable to consider that the pharmaceutical analysis of prescription at the patient admission may contribute to preventing drug-related adverse events.
How to Cite
The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.