Study of adverse reactions to paclitaxel in patients with breast cancer in a reference hospital
Keywords:Farmacovigilância, Neoplasias mamárias, Paclitaxel.
Abstracto study the adverse reactions observed in patients with breast cancer in treatment with Paclitaxel. Observational, prospective and quantitative type of study, with 24 users with non-metastatic breast cancer treated with Paclitaxel, at a reference hospital in cancer in Fortaleza-Ceará. The variables used were: social profile; dose of the medicine for body surface; infusion speed; suspect of adverse reaction immediate and late. Data were analyzed with the statistical program Epi Info version 3.5.4. The middle age was of 51.2 years (± 13 years). It was observed that the first pregnancy of 62.5% of patients occurred until their 30 years; that 70.8% breastfed for at least six months; that 58.3% stated have not used oral contraceptive; and that 58.3% had diagnosis of cancer between six months and a year before treatment. Presented adverse reactions to infusion of Paclitaxel 12.5% of patients, 71.4% of whom described in bula, 66.6% classified as moderate and 71.4% as likely to occurs, and all evolved with recovery. Patients (87.5%) reported bitter mouth, headache constipation, and abdominal pain, late adverse reactions, some not described in the drug labeling. The disease incidence was observed even in users who did not use contraceptives and breastfed, protected, according to the literature, against the occurrence of breast cancer. Ocular hyperemia and bitter mouth, new adverse reactions identified, stimulate the investigation of adverse events.
How to Cite
The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.