Drug induced liver injury: what is the clinical pharmacist role?
AbstractObejctives: Describe the drug induced liver injury, the mainly groups of drugs related, their clinical manifestation and discuss the clinical pharmacist role to the detection and management these injury. T
Methods: This is a literature research conducted through a narrative review on drug induced liver injury and the clinical pharmacist role in the detection and management of it.
Results: antibiotics, non-steroidal anti-inflammatory and anticonvulsants drugs are the main agents associated with liver injury. The toxicity may occur by direct reaction (between 24 and 48 hours after drug administration) or idiosyncratic reactions (between five and 90 days after drug administration). The clinical ranges from slight changes in liver enzymes to fulminant hepatic failure, which can progress to death. The treatment is essentially supported, however, the suspension of the drug is the first step to prevent or minimize injury.
Considerations: The detection of drug-induced liver injury depends on the establishment of the causation and the exclusion of other causes such as hepatitis B or C. The pharmacist can contribute to the early detection of drug-induced liver injury by medication reconciliation at admission, evaluation of prescription and monitoring of laboratory tests.
The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.