Non-voluntary detection method of adverse drug reactions in oncologic patients

Authors

  • ARTHUR LOPES AGRIZZI
  • LEANDRO CABRAL PEREIRA
  • PRISCILA HELENA MARIETTO FIGUEIRA

Keywords:

Reação adversa a medicamento; Farmacovigilância; Trigger Tool

Abstract

Objective: To propose the establishment of a non-volutary detection method of adverse drug reaction (ADR) through the trigger tool methodology, identifying possible indicators of adverse reactions and to compare the results obtained from the methodology used in the study and the voluntary report method used in the institution. 

Method: Prospective and descriptive study, accomplished in an oncology hospital belonging to the Rede de Hospitais Sentinelas. Initially, it was created a list of relevant triggers in the treatment of cancer patients based on the list of the Institute for Healthcare Improvement. The original methodology uses a specific computerized system to analyze prescriptions, laboratory tests and the patients admitted to the intensive care clinic, but in this study the analysis was done manually using the electronic medical record. 

Results: There were the hospitalization of 608 patients, with average length of stay of 8 days. 165 triggers were found in total, with 18 detected ADR presented by 15 patients. During the study, there were only two reports to the Pharmacovigilance sector using voluntary report, demonstrating the superiority of non-voluntary method over the method previously used, and it was responsible for detecting 89.1% of reactions in the period. Approximately 2.96% of inpatients had one or more RAM, which is consistent with literature data. 

Conclusion: The non-voluntary detection method of ADR was superior to voluntary report previously used. For adaptation of the methodology, there was no impact on routine service and had proportionally the same efficiency of a computerized system.

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Published

2019-03-11

How to Cite

1.
AGRIZZI AL, PEREIRA LC, FIGUEIRA PHM. Non-voluntary detection method of adverse drug reactions in oncologic patients. Rev Bras Farm Hosp Serv Saude [Internet]. 2019Mar.11 [cited 2024Nov.22];4(1). Available from: https://rbfhss.org.br/sbrafh/article/view/149

Issue

Vol. 4 No. 1 (2013): Jan-Mar

Section

ARTIGOS PUBLICADOS

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