Fluorouracil residues monitoring of pharmacy environments in brazilian hospital

Authors

  • RICARDO SOARES GIODA
  • HELENA CORLETA
  • EDISON CAPP
  • CARMEN PILLA

Keywords:

Citotóxicos, Monitoramento de fármacos, Fluorouracila

Abstract

Objectives: Using High Performance Liquid Chromatography, this study suggests an analytical method for monitoring cytotoxic drugs and evaluates the contamination with fluorouracil of the drug handling environment of Hospital de Clínicas de Porto Alegre, Brazil. 

 Methods: Samples were collected from surfaces, vials and gloves with wipe test technique and subsequent extraction and analysis in High Performance Liquid Chromatography equipment with Ultraviolet/Visible detection.

Results: In 96 samples collected, 19.8 % had the presence of Fluorouracil. Vials taken from the original package and sterile field of Biological Safety Cabine had higher positive results. 

Conclusions: Method used was adequate to identify the presence of fluorouracil. This allows a sensitive identification of potential contamination sources by fluorouracil residues in hospital departments, leading to adjustments of proceedings in all phases of the contact with the cytotoxic drugs.

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Published

2019-03-11

How to Cite

1.
GIODA RS, CORLETA H, CAPP E, PILLA C. Fluorouracil residues monitoring of pharmacy environments in brazilian hospital. Rev Bras Farm Hosp Serv Saude [Internet]. 2019Mar.11 [cited 2023Feb.8];3(3). Available from: https://rbfhss.org.br/sbrafh/article/view/139

Issue

Section

ARTIGOS PUBLICADOS