Fluorouracil residues monitoring of pharmacy environments in brazilian hospital
Keywords:Citotóxicos, Monitoramento de fármacos, Fluorouracila
Objectives: Using High Performance Liquid Chromatography, this study suggests an analytical method for monitoring cytotoxic drugs and evaluates the contamination with fluorouracil of the drug handling environment of Hospital de Clínicas de Porto Alegre, Brazil.
Methods: Samples were collected from surfaces, vials and gloves with wipe test technique and subsequent extraction and analysis in High Performance Liquid Chromatography equipment with Ultraviolet/Visible detection.
Results: In 96 samples collected, 19.8 % had the presence of Fluorouracil. Vials taken from the original package and sterile field of Biological Safety Cabine had higher positive results.
Conclusions: Method used was adequate to identify the presence of fluorouracil. This allows a sensitive identification of potential contamination sources by fluorouracil residues in hospital departments, leading to adjustments of proceedings in all phases of the contact with the cytotoxic drugs.
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