Implementation of clinical pharmacy services in Brazilian Hospitals: A Scoping Review

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DOI:

https://doi.org/10.30968/rbfhss.2024.151.1072

Abstract

Objective: To map studies in the literature on the implementation of clinical pharmacy services in Brazilian hospitals. Methods: A scoping review was performed, following the recommendations described in the Joanna Briggs Institute Reviewer’s Manual. A systematic search was carried out, in April 2023, in the PubMed/MEDLINE, Virtual Health Library, Web of Science, Embase and Google Scholar databases, using descriptors related to: “implementation science”, “pharmacists” and “hospitals”. Two reviewers independently analyzed the titles, abstracts, and full texts of the articles according to the eligibility criteria. Data from the included articles were extracted and presented descriptively. Results: Searches in the databases resulted in 323 articles, of which seven were included in this review. Most studies were carried out in the southeast of the country (n=4). As for the design of the studies, four was quantitative and observational and two was qualitative study. Most studies used the nomenclature “Clinical Pharmacy Service” to refer to the implemented service (n=5). Five studies did not describe in detail the method used for implementation and only one study used a framework to guide this process. As for the implementation results, most of the studies (n=4) aimed to quantify pharmaceutical interventions or the impact of the service, focusing on the impact of the pharmacist’s performance. Conclusion: This scoping review highlighted the scarcity of studies investigating the implementation of clinical pharmacy services in Brazilian hospitals. Furthermore, most studies did not describe in detail the method used for implementation. Such findings indicate the need for further studies that explore this theme, using the bases of Implementation Science, to contribute to the benefits of clinical pharmacy services being translated into clinical practice.

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References

Pizetta B, Raggi LG, Rocha KSS, et al. Does drug dispensing improve the health outcomes of patients attending community pharmacies? A systematic review. BMC Health Serv Res. 2021;21(1): 1-12. DOI: 10.1186/s12913-021-06770-0.

Newman, TV, San-Juan-Rodriguez A, Parekh N, Swart, et al. Impact of community pharmacist-led interventions in chronic disease management on clinical, utilization, and economic outcomes: an umbrella review. Res Social Adm Pharm. 2020;16(9):1155-1165.

Mekonnen AB, McLachlan AJ, Jo-anne E B. Effectiveness of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions: a systematic review and meta-analysis. BMJ open. 2016;6(2):e010003. DOI: 10.1136/bmjopen-2015-010003.

Jaam M, Naseralallah LM, Hussain TA, et al. Pharmacist-led educational interventions provided to healthcare providers to reduce medication errors: A systematic review and meta-analysis. PloS one.2021;16(6):e0253588.

Lombardi NF, Mendes AEM, Lucchetta RC, et al. Analysis of the discrepancies identified during medication reconciliation on patient admission in cardiology units: a descriptive study. Rev Lat Am Enfermagem.2016;24:e2760. DOI: 10.1590/1518-8345.0820.2760.

Magalhaes GF, Santos GBNDC, Rosa MB, et al. (2014). Medication reconciliation in patients hospitalized in a cardiology unit. PloS one. 2014;9(12):e115491. DOI: 10.1371/journal.pone.0115491.

Graça DDC. Avaliação do processo de conciliação medicamentosa em pacientes pediátricos em um hospital público especializado no estado do Rio de Janeiro [Dissertação]. Escola Nacional de Saúde Pública Sergio Arouca, Rio de Janeiro, 2015.

Moullin JC, Sabater-Hernández D, Fernandez-Llimos,F, et al. A systematic review of implementation frameworks of innovations in healthcare and resulting generic implementation framework. Health Syst Policy Res. 2015;13(1):1-11. DOI: 10.1186/s12961-015-0005-z.

Crespo-Gonzalez C, Garcia-Cardenas V, Benrimoj S I. The next phase in professional services research: From implementation to sustainability. Res Social Adm Pharm. 2017; 13(5):896-901.

Garcia-Cardenas V, Perez-Escamilla B, Fernandez-Llimos F, et al. (2018). The complexity of implementation factors in professional pharmacy services. Res Social Adm Pharm. 2018;14(5):498-500.

Tucker S, Mcnett M, Mazurek BM, et al. Implementation Science: Application of Evidence-Based Practice Models to Improve Healthcare Quality. Worldviews Evid Based Nurs.2021;18(2):76-84. DOI:10.1111/wvn.12495.

Eccles MP, Mittman BS. Welcome to implementation Science. Impl Science. 2006;1(1). DOI:10.1186/1748-5908-1-1.

Bauer MS, Damschroder L, Hagedorn H, et al. An introduction to implementation science for the non-specialist. BMC Psychol. 2015;3(1):1-12. DOI: 10.1186/s40359-015-0089-9.

Theobald S, Brandes N, Gyapong M, et al. Implementation research: new imperatives and opportunities in global health. Lancet. 2018; 392 (0160):2214-2228. DOI:10.1016/S0140-6736(18)32205-0.

Moullin JC, Sabater-Hernandez D, Benrimoj SI. Model for the evaluation of implementation programs and profesional pharmacy services. Res Social Adm Pharm. 2016;12(3):515-522. DOI: 10.1016/j.sapharm.2015.08.003.

Onozato T, Cruz CFS, Farre AGMC, et al. Factors influencing the implementation of clinical pharmacy services for hospitalized patients: A mixed-methods systematic review Res Social Adm Pharm. 2020;16:437-449. DOI: 10.1016/j.sapharm.2019.06.018.

Cerqueira SS, Rocha KS, Araújo DC, et al. Which factors may influence the implementation of drug dispensing in community pharmacies? A qualitative study. J Eval Clin Pract. 2023;29(1):83-93. DOI:10.1111/jep.13731.

Dosea AS, Brito GC, Santos LM, et al. Establishment, implementation, and consolidation of clinical pharmacy services in community pharmacies: perceptions of a group of pharmacists. Qual Health Res. 2017;27(3):363-373. DOI: 10.1177/104973231561429.

Detoni KB, Nascimento MMG, Oliveira IV, et al. Comprehensive medication management services in a brazilian speciality pharmacy: a qualitative assessment. Int J Pharm Pharm Sci. 2017; 9(3):227-232. DOI: 10.22159/ijpps.2017v9i3.16398.

Ramos SF, Santos Júnior GAD, Pereira AM, et al. Facilitators and strategies to implement clinical pharmacy services in a metropolis in Northeast Brazil: a qualitative approach. BMC Health Serv Res. 2018;18(1): 1-12.

Santos Júnior GAD, Ramos SF, Pereira AM, et al. Perceived barriers to the implementation of clinical pharmacy services in a metropolis in Northeast Brazil. PLoS One. 2018;13(10):e0206115. DOI: 10.1371/journal.pone.0206115.

Peters MDJ, Marnie C, Tricco AC, et al. Updated methodo-logical guidance for the conduct of scoping reviews. JBI EvidSynth. 2020;18(10): 2119-2126. DOI: 10.11124/JBIES-20-00167.

Tricco AC, Lillie E, Zarin W, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann InternMed. 2018;169(7):467-473. DOI: 10.7326/M18-0850

Ouzzani M, Hammady H, Fedorowicz Z,et al. Rayyan — um aplicativo web e móvel para revisões sistemáticas. 2016;5(1):1–10. DOI:10.1186/s13643-016-0384-4.

Alcântara TDS, Onozato T, Araújo Neto FDC, et al. Perceptions of a group of hospital pharmacists and other professionals of the implementation of clinical pharmacy at a high complexity public hospital in Brazil. BMC Health Serv Res. 2018;18 (1):242. DOI: 10.1186/s12913-018-3036-7.

Fernandes BD, Foppa AA, Ayres LR, et al. Implementation of Medication Reconciliation conducted by hospital pharmacists: A case study guided by the Consolidated Framework for Implementation Research. Res Social Adm Pharm. 2022;18(9):3631-3637. DOI: 10.1016/j.sapharm.2022.01.010.

Farias TF, Aguiar KDS, Rotta I, et al. Implementação de um serviço farmacêutico clínico em hematologia. Einstein. 2016;14(3):384-90. DOI: 10.1590/S1679-45082016AO3667.

Ferracini FT, Almeida SMD, Locatelli J, et al. Implantação e evolução da farmácia clínica no uso racional de medicamentos em hospital terciário de grande porte. Einstein. 2011; 9(4):456-60. DOI: 10.1590/S1679-45082011AO2140.

Magalhães ACAF, Cantanhede AMFC, Drummond BM, et al. Avaliação da implantação do serviço de farmácia clínica na Unidade de Terapia Intensiva para contribuir na segurança do paciente. Rev Assoc Med Minas Gerais.2016; 26(5):16-22.

Oliveira AMD, Varallo FR, Rodrigues JPV, et al. Protocolo da implantação do cuidado farmacêutico na geriatria: estratégia para segurança na assistência à saúde. Rev Gaucha Enferm. 2022; 43(1): e20210236. DOI: 10.1590/1983-1447.2022.20210236.

Okumura LM, Da Silva DM, Comarella L. Relação entre o uso seguro de medicamentos e serviços de farmácia clínica em Unidades de Cuidados Intensivos Pediátricos. Rev Paul Pediatr. 2016;34(4):397-402. DOI: 10.1016/j.rppede.2016.04.001.

Conselho Federal De Farmácia (CFF). Serviço farmacêutico diretamente destinado ao paciente, à Família e à comunidade. Brasília: Conselho Federal de Farmácia, 2016. Disponível em: https://www.cff.org.br/userfiles/Profar_Arcabouco_TELA_FINAL.pdf. Acesso em 1 jun. 2023.

Sociedade Brasileira De Farmácia Clínica (SBFC). Origem da farmácia clínica no Brasil, seu desenvolvimento, conceitos re lacionados e perspectivas Documento de posição da SBFC/Sociedade Brasileira de Farmácia Clínica. Brasília: Sociedade Brasileira de Farmácia Clínica, 2019. Disponível em: https://farmaciaclinica.org.br/wp-content/uploads/2022/01/SBFC_Documento-de-posicao_Versao-final_2020_01_17_Revisao-formatacao_Silvia_2020_01_19_v_final.pdf. Acesso em: 8 jan. 2023.

Seynaeve S, Verbrugghe W, Claes B, et al. Adverse drug events in intensive care units: a cross-sectional study of prevalence and risk factors. Am J Crit Care. 2011;20 (6):e131–e140. DOI: 10.4037/ajcc2011818.

Pilau R, Heineck I, Hegele V. Atuação do farmacêutico clínico em unidade de terapia intensiva adulto: uma revisão da literatura. Rev Bras Farm Hosp Serv Saude. 2014; 5(1): 19-24.

Moura C, Prado N, Acurcio F. Potential drug-drug interactions associated with prolonged stays in the intensive care unit: a retrospective cohort study. Clin Drug Investig. 2011;31:309-316. DOI: 10.1007/BF03256929.

Conselho Federal De Farmácia(CFF). Resolução nº 675 de 2019. Regulamenta as atribuições do farmacêutico clínico em unidades de terapia intensiva. Brasília: Conselho Federal de Farmácia. 2019. Disponível em: https://abmes.org.br/arquivos/legislacoes/Resolucao-CFF-675-2019-10-31.pdf. Acesso em: 4 jan. 2023.

Morris ZS, Wooding S, Grant J. The answer is 17 years, what is the question: understanding time lags in translational research. J R Soc Med. 2011; 104(12): 510-520. DOI: 10.1258/jrsm.2011.110180.

Peters DH, Adam T, Alonge O, et al. Implementation research: what it is and how to do it. Bmj. 2013;347:f6753. DOI:10.1136/bmj.f6753.

Fixsen DL, Naoom SF, Blase KA, et al. Implementation research: A synthesis of the literature, ed 231. Tampa, FL: University of South Florida, Louis de la parte Mental Health Institute: The National Institute Research Network; 2005.

Brandt J, Lê ML, Jantscher S, et al. Medication review service implementation in community pharmacy settings: scoping review with focus on implementation studies. Res Social Adm Pharm. 2020;16(7):875-885. DOI:10.1016/j.sapharm.2019.10.005.

Proctor E, Silmere H, Raghavan R, et al. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Adm Policy Ment Health. 2011;38(2):65–76. DOI: 10.1007/s10488-010-0319-7.

Published

2024-03-23

How to Cite

1.
TAVARES AL, BRASIL LX, JAVARINI HV, SANTOS-JÚNIOR GA, ARAÚJO DC, ROCHA KS. Implementation of clinical pharmacy services in Brazilian Hospitals: A Scoping Review. Rev Bras Farm Hosp Serv Saude [Internet]. 2024Mar.23 [cited 2024Nov.22];15(1):1072. Available from: https://rbfhss.org.br/sbrafh/article/view/1072

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ORIGINAL ARTICLES