Evaluation of potential interactions of oral medications prescribed in a kidney and liver transplant unit
Objective: To identify, quantify and classify, according to the degree of severity, potential drug interactions (PDI) present in prescriptions for oral medications for patients admitted to a transplant unit. Methods: This is a descriptive and retrospective cross-sectional study based on the prescriptions of patients admitted to a kidney and liver transplantation unit. Where data were collected from 831 prescriptions and from this total, 223 were selected, which were submitted to the tracking of possible drug-drug interactions using the online tool Micromedex®. Results: The selected prescriptions had between 1 and 21 drugs (mean of 8 ± 4), with 216 potential drug interactions identified; of this total, the following results were found regarding the severity of these potential events: major (62.03%), moderate (31.94%) and minor (6.01%). Through the analysis carried out, a total of 66.66% (n=46) of the evaluated patients presented potential drug interactions in their prescriptions, with an average of 3.13 PDI per patient. It was possible to observe that more than 50% of patients had potential drug interactions in their prescriptions, among which immunosuppressants were involved in 49.52% of all interactions. Conclusion: It was possible to observe that the high frequency of potential drug interactions in transplant patients is possibly due to the amount of drugs prescribed concomitantly, due to the various comorbidities that these patients have, since the greater the number of drugs prescribed, the greater the probability of having this type of interaction. The most common PDIs were of greater severity, which highlights the importance of patient monitoring for adequate decision-making by the clinical staff, promoting patient safety.
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