Lactobacillus acidophilus associated with other probiotics alters the microbiota of colorectal cancer patients: systematic review

Authors

DOI:

https://doi.org/10.30968/rbfhss.2022.131.0746

Abstract

Objective: Microbiome is an important factor for the development and progression of colorectal cancer. The aim of the study was to carry out a systematic review to verify whether the administration of food or pharmaceutical formulations containing the bacterium Lactobacillus acidophilus, alone or associated with other bacteria and substances could alter the intestinal microbiota in colorectal cancer patients. Methods: The review of randomized trials compared the use of L. acidophilus versus placebo or samples of healthy patients without intervention. Results: Two independent reviewers performed the search and found 1,060 articles, with the preliminary selection of 22 articles that were read in full and 04 articles that were included in the systematic review. The included articles worked with pharmaceutical formulations containing L. acidophilus associated with other probiotic bacteria and prebiotic fibers. The results showed that the administration of formulations in patients with colorectal cancer was for less than 31 days, underwent colonoscopy or surgical resection with qualitative and quantitative changes in the microbiota of the individuals included compared to those who received placebo formulation or were under healthy control. Conclusions: The alterations found demonstrate that probiotics had the ability to modulate the microbiota to a profile close to that found by healthy patients.

 

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Author Biography

Luciana O. FARIÑA

Professora Dra do Centro de Ciências Médicas e Farmacêuticas da Universidade Estadual do Oeste do Paraná, Docente dos Programas de Pós-Graduação em Desenvolvimento Rural e Sustentável pelo Campus de Marechal Cândido Rondon e de Ciências Farmacêuticas do Campus de Cascavel e da graduação em Farmácia. 

Published

2022-03-30

How to Cite

1.
FURTADO BB, FARIÑA LO. Lactobacillus acidophilus associated with other probiotics alters the microbiota of colorectal cancer patients: systematic review. Rev Bras Farm Hosp Serv Saude [Internet]. 2022Mar.30 [cited 2024Jun.16];13(1):746. Available from: https://rbfhss.org.br/sbrafh/article/view/746

Issue

Section

ORIGINAL ARTICLES