Methotrexate in the treatment of ectopic pregnancy: retrospective analysis of risks in therapeutic protocol

Authors

  • FRANCISCO ALVES FARIAS- FILHO
  • JULIANA SILVEIRA DE OLIVEIRA
  • KELLY DE ALMEIDA MELO
  • ALESSANDRA NOVIS GOMES
  • MARCELO SOBRAL LEITE
  • MARCELO SOBRAL

Keywords:

Gravidez ectópica, metotrexato, interações medicamentosas

Abstract

Ectopic pregnancy is characterized as pregnancy in places other than the uterus, such as abdominal cavity, ovaries and fallopian tubes and is associated with maternal morbidity and mortality in the first trimester of pregnancy. Pharmacotherapy with methotrexate for ectopic pregnancy treatment has a significant clinical importance in the management of Ectopic pregnancy. As an antimetabolic and antineoplasic drug, methotrexate treatment requires pharmacotherapeutic monitoring, risk analysis studies of the administration process of this drug are warranted. In a retrospective cross-sectional study we analyzed 10 cases of patients with ectopic pregnancy that made use of methotrexate in a maternity hospital in Rio de Janeiro, Brazil. The protocols in a single intramuscularly dose were adopted in 83% of cases, according to international trend. It was observed that in none of the prescriptions analyzed the body surface was mentioned, and therefore considered non-compliant. In the patients studied, 60% received doses of 50 mg of methotrexate. The evaluation of renal and hepatic function was not performed in 30% of cases and 60% of then received drugs in potential interactions with methotrexate . These findings emphasize the need for greater involvement of the pharmacist in pharmacotherapy protocol standardization and monitoring of methotrexate treatment in ectopic pregnancy.

Downloads

Download data is not yet available.

Downloads

Published

2019-03-11

How to Cite

1.
FILHO FAF-, OLIVEIRA JSD, MELO KDA, GOMES AN, LEITE MS, SOBRAL M. Methotrexate in the treatment of ectopic pregnancy: retrospective analysis of risks in therapeutic protocol. Rev Bras Farm Hosp Serv Saude [Internet]. 2019Mar.11 [cited 2024Nov.16];5(1). Available from: https://rbfhss.org.br/sbrafh/article/view/186

Issue

Vol. 5 No. 1 (2014): Jan-Mar

Section

ARTIGOS PUBLICADOS

License

The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

 

Serlf-archiving policy

This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.