@article{TANIMOTO_FREITAS_GUIMARAES_COSTA_2018, title={Identification of the occurrence of hyponatremia in hospitalized elderly using weak opioids}, volume={9}, url={https://rbfhss.org.br/sbrafh/article/view/311}, DOI={10.30968/rbfhss.2018.091.002}, abstractNote={<p><strong>ABSTRACT</strong><br>Background: Drug-induced hepatitis, also called toxic hepatitis or DILI (Drug Induced Liver Injury),<br>accounts for about 2% of hospitalization cases of jaundice and liver damage is involved in 3-10% of all<br>adverse drug reactions. Cases of hepatic injury associated with ibuprofen use are rare and the frequency<br>of idiosyncratic hepatotoxicity is small. Objective: To report a case of hepatic injury induced by<br>ibuprofen identified in a medium complexity outpatient clinic. Case report: A 48-year-old female patient<br>was admitted to a Specialized Care Center in the southwestern state of Bahia for a consultation with an<br>orthopedist complaining of low back pain, and ibuprofen and sodium dipyrone were prescribed to relieve<br>symptoms. After 15 days of treatment, the patient returns to the service complaining of arthralgia in the<br>upper limbs, right hand edema, jaundice, coluria, fecal suppura, asthenia and intense pruritus. From the<br>investigation of the presented case, viral and autoimmune etiologies were ruled out. Ultrasonography of the total abdomen showed a slight abnormal texture of the liver and gallstones in motion, being suggestive of choledocholithiasis. After evaluation of causality and application of RUCAM, the reaction was classified as highly probable. Conclusions: The hepatic injury shown by the patient has a strong causal relationship with the use of ibuprofen.</p>}, number={1}, journal={Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde}, author={TANIMOTO, FERNANDA ALICE and FREITAS, POLLYANNA EVELYN FERREIRA and GUIMARAES, HENRIQUE CERQUEIRA and COSTA, JOSIANE MOREIRA DA}, year={2018}, month={Mar.} }