Medication therapy management in patients with tuberculosis and HIV/AIDS: case series

Abstract

Objectives: To describe cases of patients with tuberculosis (TB) and HIV / AIDS coinfection followed up at a Reference Hospital in infectious diseases. Identify, classify, and resolve the Drug Related Problems (DRP). And classify the clinical and pharmacotherapeutical situation. Methods: For the identification, classification, and resolution of the DRP outcome as well as the clinical and pharmacotherapeutical situation, the Pharmacotherapy Workup methodology was used. This is na observational, descriptive, longitudinal, case series study carried out in a tertiary referral hospital in Belo Horizonte, following CARE guidelines endorsed by Enhancing the QUAlity and Transparency Of health Research (EQUATOR) Network. Patients coinfected with TB and HIV/AIDS, exposed to the treatment recommended by the Ministry of Health, aged 18 years or older, of both genders, followed for a minimum period of six months, were included. Results: Six cases of patients co-infected with TB and HIV/AIDS were described. The average number of meetings with the pharmacist was 6.33 (standard deviation=0.82). A total of 69 DRPs were identified, of which 40/69 (58.0%) were related to adherence, 17/69 (24.6%) to the indication, 8/69 (11.6%) to safety and 4/69 (5.8%) to effectiveness. Of the total number of patients 4/6 (66.6%) had hepatotoxicity during follow-up. The clinical and pharmacotherapeutical situation was classified as positive for all patients. Conclusion: There was a high number of adherence and indication DRP in coinfected patients. Monitoring the effectiveness and safety of treatments must be carried out, due to the greater susceptibility to adverse reactions, such as hepatotoxicity.