Profile of drug utilization in pediatric patients in intensive care
Keywords:
Pediatria; Unidades de Terapia Intensiva; Uso de medicamentos.Abstract
Objectives: To analyze the profile use of medications in the pediatric Intensive Care Unit (PICU) of a university hospital. Methods: Cross-sectional, retrospective, observational study, which evaluated 174 patients younger than 18 years who were hospitalized at least 24 hours in the hospital's PICU. The prescription drugs were classified according to their use in children as approved, off-label (OL) and unlicensed (UL), and also according to the classification Anatomical Therapeutic Chemical (ATC). The comparison of drugs in age groups was performed using the Kruskal-Wallis test for the UL drugs, and OL medicines and approved were compared by ANOVA One-Way with a significance level of 0.05. Results: Of the analyzed patients 54.60% were male and the age group infant was the most prevalent (46.55%). The postoperative (43.10%) was the leading cause of hospitalization in the PICU. There were analyzed 1939 prescription items, averaging 11.15 ± 5.8 drugs per patient. The most frequently prescribed drugs were active in the nervous system (N group). It was observed that the total number of items were 47.94% of OL use, 39.5% of approved use, 6.4% of UL use and 6.2% of OL use and UL concomitantly. There was no statistical difference between the approved drugs, UL and OL within the age groups. Conclusions: The results confirm the high prevalence of OL and UL drugs in PICU uses, which is in according with studies found in the literature, confirming the need for more studies be conducted in this area.
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