Drug administration by hypodermoclysis: a review of literature
Method: A non systematic literature review in Medline library databases (Medical Literature Analysis and Retrieval System Online) with PubMed and BVS (Virtual Health Library)´s interface.
Results: A total of 21 articles with information on drug administration techniques by hypodermoclysis were found, which relied on the identification of 78 drugs, with only 53 drugs offering information on the dose used in hypodermoclysis. Information concerning diluents to be used and other administration criteria were identified, respectively, for a quantity of 56 and 47 drugs. The drugs with greater frequency in reference articles were morphine, metoclopramide, haloperidol, midazolam, butylscopolamine and dexamethasone, which were described in more than 10 items. There were records of adverse reactions related to 49 drugs, and the most common reactions were pain, inflammation and edema at the application site.
Conclusion: Few studies have been found to compose the review, especially regarding aspects of drugs efficacy and safety. It is expected that this review will point to the need to obtain more information about the use of this route of administration.
The authors hereby transfer, assign, or otherwise convey to RBFHSS: (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to RHFHSS with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.