Potential drug interactions in intensive care unit adult of a public state hospital

Authors

  • ANA HELENA DA SILVA GIMENES
  • MÁRCIA MARIA FERREIRA BARONI
  • PAULA JULIANI NASCIMENTO RODRIGUES

Abstract

OBJECTIVE: To identify potential drug interactions in adult intensive care unit of a public hospital. METHODS: A retrospective, observational, cross-sectional study in adult intensive care unit. Prescribed drugs were collected from medical prescriptions to analyze the occurrence of potential drug interactions and classification, using the database Micromedex® DrugReax®. RESULTS: A total of 289 medical prescriptions and 65.40% of these showed some potential drug interactions. These were classified according to severity in: contraindicated 8 (0.97%), severe 412 (50.25%), moderate 347 (42.32%) and lowest 53 (6.46%). The severity and were grouped according to the documentation available. Potential drug interactions were characterized by risk they involved, including cardiotoxicity and problems related to the central nervous system 57.3% of the 948 identified risks. Were also characterized the management and monitoring strategies for each potential drug interactions identified, and dose adjustment of one or both drugs that interact and monitoring of signs and symptoms frequently with 69.05%. CONCLUSION: The results contribute to the risk profile of the design on the potential drug interactions in intensive care unit and demonstrates the need for performance of clinical pharmacist in this area in order to contribute to the multidisciplinary team in the reduction of risks from therapy drug.

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Published

2019-03-11

How to Cite

1.
GIMENES AHDS, BARONI MMF, RODRIGUES PJN. Potential drug interactions in intensive care unit adult of a public state hospital. Rev Bras Farm Hosp Serv Saude [Internet]. 2019Mar.11 [cited 2024Feb.22];5(4). Available from: https://rbfhss.org.br/sbrafh/article/view/207

Issue

Section

ARTIGOS PUBLICADOS

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